WebApr 11, 2024 · Based on long and densely packed DNA structure, it could efficiently induce liquid phase condensation of cGAS and activate STING signaling to produce inflammatory cytokines. Moreover, this virus-like particle could also trigger the formation of AIM2 inflammasome to induce gasdermin D-mediated pyroptosis, boosting antitumor immunity. WebJul 11, 2024 · Primer. cGAS–STING signaling. Cyclic GMP–AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) …

cGAS-STING signaling in cancer immunity and immunotherapy

WebThe cGAS-STING pathway has emerged as the major pathway for DNA sensing and plays a fundamental role in microbial surveillance. The role of this pathway in antiviral immunity makes it highly attractive for antivirus therapy or vaccine adjuvants. However, cGAS is a universal DNA sensor and cannot discriminate self from non-self DNA, thus both ... Webcytokine responses. Most recently, cGAS was shown to be critical for the recognition of cytoplasmic dsDNA. Binding of dsDNA to cGAS results in the synthesis of cGAMP(20–50), which then binds to the endoplasmic reticulum resident protein STING. This initiates a signaling cascade that triggers the induction of an antiviral immune response. harvey norman office chairs online

SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING …

WebThe cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase ( cGAS) triggers reaction of … WebCells lacking cGAS, STING, and IRF3/-7 also displayed significantly reduced levels of AIM2 induction relative to that in control cells, although to a lesser degree than following IFNAR1 deletion ... WebMar 21, 2024 · cGAS N-terminal R/K-rich region is essential for its physiological function Summary Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. harvey norman office chair