Dynamo mapping vector field of single cells

Web•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. WebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, differential geometry analyses, and most probably paths / in silico perturbation predictions. Installation - Ten minutes to dynamo - …

Mapping transcriptomic vector fields of single cells

WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions. WebHome: Cell Press lithium batteries versus alkaline batteries https://bowlerarcsteelworx.com

Mapping transcriptomic vector fields of single cells.

WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction of single-cell vector field functions with the resultant cell state and velocity samples, 3) in-depth analyses leveraging various differential geometry analyses, and 4) predictions of ... WebMar 31, 2024 · Wagner, D. E. et al. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science 360, ... Qiu, X. et al. Mapping vector field of single cells. WebDynamo. : Mapping Vector Field of Single Cells. Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these … improving fitness tips

Dynamo : Mapping Vector Field of Single Cells - Read the Docs

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Dynamo mapping vector field of single cells

Dynamo: Mapping Vector Field of Single Cells — dynamo 1.1.0 docum…

WebSingle-cell (sc)-RNA-seq, together with RNA-velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, … WebFeb 17, 2024 · In this work, we introduced dynamical systems theory and differential geometry analyses to single-cell genomics. A dynamical system describes the time …

Dynamo mapping vector field of single cells

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Web•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell … WebJul 9, 2024 · Here, we introduce dynamo , an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity vector fields that predict future cell fates, and finally employs differential geometry analyses to elucidate the underlying regulatory networks.

WebFeb 1, 2024 · Dynamo is a computational framework for gaining insights into dynamic biological processes, such as human hematopoiesis, from time-resolved single-cell RNA-seq data. Dynamo constructs … WebJul 9, 2024 · Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …

WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - GitHub - KBRI-Biology-Experiment-Comput... WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction …

WebFeb 2, 2024 · Researchers at the Whitehead Institute for Biomedical Research and other centers describe a computational approach called dynamo, which they used to retrace RNA velocity and single-cell transcriptomic "vector fields," and regulatory features from time-resolved single-cell RNA sequence data. "This framework represents a notable advance …

WebDynamo: Mapping Vector Field of Single Cells¶ Understanding how gene expression in single cells progress over time is vital for revealing the mechanisms governing cell fate … improving fitnessWebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-... improving fit right homeWebFeb 1, 2024 · The researchers confirmed dynamo 's cell fate predictions by testing it against cloned cells-cells that share the same genetics and ancestry. One of two nearly-identical clones would be sequenced ... improving fitness quicklyWebAug 8, 2024 · In large datasets, it is easier to visualize the prevalent pattern of cell velocities with locally averaged vector fields (Fig. 2i). Because cells can have RNA velocities along multiple ... improving fleet performanceWebFeb 17, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting … lithium batteries vs rechargeableWebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these … improving flexibility quizlethttp://dynamo-readthedocs.readthedocs.io/ improving flexibility