Tfr1 cancer
WebTfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. TfR2 binds to transferrin with a 25-30 fold lower affinity … Web10 Nov 2024 · Other studies have shown that targeting TFR1 can suppress tumor progression, such as MiR-107 can inhibit the proliferation, migration, and invasion of …
Tfr1 cancer
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Web9 Apr 2024 · Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells. ... TfR1 … Web15 Jun 2024 · Abstract. Transferrin receptor protein 1 (TFR1), also known as CD71, is a cell surface receptor that plays a major role in cellular iron uptake via receptor-mediated …
WebThe expression of iron import proteins, such as transferrin receptor (TfR1) and iron-storage protein, ferritin in aggressive breast cancer cells are frequently elevated, while the levels … Web22 Mar 2024 · TfR1 in gliomas increases iron accumulation and promotes tumor progression by two mechanisms: an increase in the proliferation rate and glutamate production. (14) TfR2 is also highly expressed in …
Web10 Mar 2024 · The antigen of 3F3-FMA is identified as the transferrin receptor 1 protein (TfR1) • Anti-TfR1 antibodies can detect ferroptosis by immunofluorescence and flow … Web4 Sep 2024 · TfR1 is the main protein responsible for iron absorption. Strong immunohistochemical staining of TfR1 could indicate high cancer cell proliferation and …
Web10 Mar 2024 · We also tested the 3F3-FMA antibody in several cancer cell lines and identified the antigen of 3F3-FMA as transferrin receptor protein 1 (TfR1). TfR1 imports …
Web5 Aug 2011 · The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin. This receptor is an attractive molecule for the targeted therapy of cancer since it is... duty cycle of flyback converterWeb23 Jan 2024 · Transferrin receptor 1 (TfR1), encoded by TFRC, is a key regulator of iron homeostasis and plays important roles in many diseases, including cancers. Objective To … crystal beach boardwalk hotel ocean city mdWeb14 Apr 2024 · Abstract. Therapeutic antibodies have been successfully used to treat several diseases, such as cancers and autoimmune diseases. However, the utility of conventional antibodies for neurological conditions is limited by the blood-brain barrier (BBB). Several strategies to address this issue have been reported, including receptor-mediated … crystal beach bolivar peninsula texas rentalsWeb2 Sep 2024 · Ribonucleotide reductase (RR) is the rate-limiting enzyme that controls the deoxynucleotide triphosphate synthesis and it is an important target of cancer treatment, since it is expressed in tumor cells in proportion to their proliferation rate, their invasiveness and poor prognosis. Didox, a derivative of hydroxyurea (HU), is one of the most potent … crystal beach cabins for rentWebSeveral cancer cell lines express higher levels of the TfR1 protein compared to the normal cells, and the TfR1 expression level is correlated with the malignancy [9–11]. Hence, intracellular iron and TfR1 have been considered as the targets of cancer therapies [12]. crystal beach bolivar vacation rentalscrystal beach business for saleWeb13 Sep 2024 · Abstract Breast cancer (BC) is the most common malignancy with high morbidity and mortality in females worldwide. Emerging evidence indicates that … duty cycle of buck converter formula