The mechanical memory of lung myofibroblasts

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Splet10. jul. 2024 · Myofibroblast activation is jointly promoted by chemical and mechanical stimuli that establish positive feedback loops, which are central in the pathogenesis of … SpletNanoscale geometry determines mechanical biocompatibility of vertically aligned nanofibers. Samuel Rantataro, Ilmari ... Shape Memory Polymer-Based Insertable Electrode Array towards Minimally Invasive Subdural Implantation ... Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density ...

Mechanical priming impacts cell number, collagen production, and …

Splet19. nov. 2024 · The effects of past mechanical cues on cells can persist long after the removal of those cues. Such behavior has been called “mechanical memory”.5,14 Early evidence of mechanical memory in the context of hydrogel stiffness came from experiments with primary rat lung fibroblasts which were cultured on a PDMS substrate … edge 終了コマンドプロンプト

The mechanical memory of lung myofibroblasts. - Wikidata

SpletThe myofibroblast, a key cell in normal and pathological tissue repair. Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility … SpletHence, mechano-sensed information relating to physical conditions of the local cellular environment could permanently induce fibrotic behavior of lung fibroblasts. This priming … SpletIn addition, the mechanical properties of the extracellular matrix, such as its deformability (stiffness, rigidity), can importantly modulate cellular functions. Recently, matrix stiffness has been highlighted as a potential contributor to the pathogenesis of pulmonary fibrosis. ... The mechanical memory of lung myofibroblasts. Integr Biol ... edge 終了時キャッシュクリア

Metformin attenuates ventilator-induced lung injury

Time course evaluation of priming events. Lung fibroblasts were ...

Splet01. jul. 2024 · Fibrotic disease is driven by dysregulation in mechanical forces at the organ, tissue, and cellular level. While it is known that, in certain pathologies, diseased cells are stiffer than healthy cells, it is not known if fibroblasts derived from patients with IPF are stiffer than their normal counterparts. SpletWith increasing stiffness, myofibroblasts first appear on 25 kPa substrates and subsequently increase in number and distribution on 5–100 kPa models. ... The mechanical memory of lung ... edge 終了ショートカットSpletTo test whether lung ﬁbroblasts possess such a mechanical memory, we establish herein a cell culture system to directly isolate and sub-culture lung ﬁbroblasts on silicone … edge 終了しない

"Splet01. apr. 2012 · The mechanical memory of lung myofibroblasts Introduction. One of the quintessential features in all forms of connective tissue fibrosis is the replacement of … " - The mechanical memory of lung myofibroblasts

The mechanical memory of lung myofibroblasts

SpletThis review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly … Splet13. mar. 2012 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our …

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Splet01. apr. 2024 · The mechanical memory of lung myofibroblasts. Integr. Biol. (2012) M. Waghray et al. Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J. … SpletIntroduction Diabetic patients may develop acute lung injury less often than non-diabetics; a fact that could be partially ascribed to the usage of antidiabetic drugs, including metformin. Metformin exhibits pleiotropic properties which make it potentially beneficial against lung injury. We hypothesized that pretreatment with metformin preserves alveolar capillary …

Splet02. jan. 2024 · In MPCs, increased stiffness mediates acquisition of mechanical memory by causing a sustained increase of miR-21, a positive regulator of ECM deposition . ... we regard the concept of a distinct fibrogenic niche with fibrogenic progenitors as the source of activated myofibroblasts in progressive lung and liver fibrosis not as fact, but as one ... Splet27. okt. 2024 · Lung-resident mesenchymal stem cells (MSCs) defined by ABCG2-lineage (ABCG2 +) have been shown to transition to myofibroblasts in vitro upon stimulation with …

SpletHence, mechano-sensed information relating to physical conditions of the local cellular environment could permanently induce fibrotic behavior of lung fibroblasts. This priming effect has important implications for the progression and persistence of aggressive fibrotic diseases such as idiopathic pulmonary fibrosis. Agid: 6630694 SpletMyofibroblasts are specialized contractile cells that participate in tissue fibrosis and remodeling, including idiopathic pulmonary fibrosis (IPF). Mechanotransduction, a process by which mechanical stimuli are converted into biochemical signals, regulates myofibroblast differentiation.

SpletThe mechanical memory of lung myofibroblasts. scientific article published on 13 March 2012. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed Central. PubMed ID. 22410748. retrieved.

SpletThe mechanical memory of lung myofibroblasts Read by QxMD Fibroblasts differentiate into the highly synthetic and contractile myofibroblast phenotype when exposed to … edge 縦スクロールバー表示されないSplet01. apr. 2012 · It is established that myofibroblast contraction functions as a mechanism to directly activate TGF-β1 from self-generated stores in the extracellular matrix (ECM), … edge 終了時に閲覧の履歴を削除するSplet22. dec. 2024 · These studies suggest that mechanical interactions at the cell–substrate interface play a key role in regulating this phenotype transition by changing the mechanical and morphological properties of the cells. Here, we briefly summarize the reported chemical and physical cues regulating fibroblast phenotype. ... The mechanical memory of lung ... edge 終了バッチSplet01. jun. 2024 · In lungs, the major sources are interstitial fibroblasts, BM-derived fibrocytes, mesothelial cells, and epithelial alveolar cells. Chronic pulmonary injury results in IPF [72 ]. Furthermore, these tissues have significant amount of blood flow through specialized vessels including the liver sinusoids, kidney glomeruli, and pulmonary blood vessels. edge 縦スクロールバーSplet23. jul. 2024 · Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in pathophysiological processes. Myofibroblasts mediate wound contractions, but their persistent presence in tissues is central to driving fibrosis, making them attractive cell targets for the development of therapeutic treatments. edge 翻訳アイコンSplet15. mar. 2024 · Fibrosis is associated with numerous heart, lung, and vascular diseases, and is implicated in an estimated 45% of all deaths in the developed world [25, 26]. ... The mechanical memory of lung myofibroblasts. Integr. Biol., 4 (2012), pp. 410-421. CrossRef View in Scopus Google Scholar [40] edge 翻訳アイコンが表示されないSpletThe mechanical properties of scarred lung and fibrotic foci promote myofibroblast contraction and differentiation. One essential element in this detrimental feed-forward … edge 繋がらない ie 繋がる